Taysha Gene Therapies
Background
Taysha Gene Therapies is a clinical-stage biotechnology company operating in a highly regulated environment where data security, compliance, and controlled collaboration are mission-critical.
With enterprise-grade Microsoft 365 E5 licensing, Taysha already had a mature security and compliance framework in place. However, enabling secure collaboration with external stakeholders—while maintaining full control over sensitive data—remained a key architectural consideration.
Challenges
While leveraging an existing Virtual Data Room (VDR), Taysha faced structural limitations common to traditional VDR platforms:
- Data residency outside the Microsoft 365 tenant
→ Sensitive documents stored in third-party infrastructure, introducing governance and security concerns - Fragmented compliance model
→ Security, audit, and legal controls not fully aligned with Microsoft Purview and existing policies - Limited visibility and control across user roles
→ Need for clearer governance between Owners, Collaborators, and Viewers - Operational inefficiencies in managing secure collaboration
→ Internal and external users operating across disconnected environments - Cost inefficiencies (“VDR tax”)
→ Traditional pricing models based on storage, users, or transactions rather than leveraging existing M365 investment
These challenges created a gap between enterprise-grade compliance expectations and actual collaboration infrastructure.
Solution
Govern 365 introduced a fundamentally different approach to Virtual Data Rooms—built natively inside Microsoft 365, not layered on top of it.
Key capabilities aligned to Taysha’s requirements included:
- Tenant-native data architecture
→ All documents remain within the organization’s Microsoft 365 tenant
→ Eliminates third-party data exposure and ensures full data sovereignty - Deep integration with Microsoft Purview & E5 compliance stack
→ Sensitivity labels, retention policies, audit logs, and legal holds applied natively
→ No duplication of governance frameworks - Granular, role-based governance model
→ Clear separation of permissions across VDR Owners, Collaborators, and Viewers
→ Full visibility and control over user actions - Secure external collaboration without data movement
→ Cross-tenant access managed within Microsoft identity and security boundaries - Advanced VDR controls
→ Audit trails, watermarking, controlled access, and legal hold readiness - Elimination of “VDR tax”
→ No per-page, per-user, or storage-based pricing
→ Leverages existing Microsoft 365 infrastructure and licensing
This architecture allowed Taysha to replace an external, siloed VDR model with a unified, enterprise-native solution.
Benefits
By aligning secure collaboration with its existing Microsoft ecosystem, Taysha achieved:
- Complete data sovereignty
→ All sensitive content remains within their Microsoft 365 tenant - Unified compliance and governance
→ Security, audit, and legal controls fully aligned with Microsoft Purview - Reduced risk surface
→ Elimination of third-party storage and external data duplication - Improved operational efficiency
→ Single platform for internal and external collaboration - Cost optimization
→ Removal of traditional VDR pricing overhead (“VDR tax”) - Scalable, future-ready collaboration infrastructure
→ Ready for use cases such as M&A, regulatory submissions, and partner collaboration
Govern 365 helps companies like Taysha Gene Therapies eliminate VDR risk, accelerate secure collaboration, and maintain complete control over sensitive data—directly within Microsoft 365.
